A UK Comparison Explained by Specialists
Choosing the right weight loss injection can feel overwhelming. With multiple options available in the UK, each with different dosing schedules, benefits, and eligibility criteria, it is important to understand what is most appropriate for you, not just what is most popular.
At Harley Street Obesity Clinic, our team has a proven track record in medical and surgical weight management. We are not a prescription-only clinic; we provide full clinical oversight, personalised plans, and long-term support. This ensures that whichever injection you choose is safe, effective, and aligned with your goals.
Why Consider Weight Loss Injections?
Modern GLP-1 weight loss medications help regulate appetite, improve metabolic health, and support sustainable weight loss. They can be particularly effective if you:
- Are beginning your weight-loss journey
- Have tried other methods without significant or long-term success
- Are experiencing a plateau
- Have regained weight after previous treatment, surgery, or diets
- Are looking for non-surgical alternatives to revision bariatric procedures
Choosing the correct medication is critical to achieving the best results.
UK Weight Loss Injection Comparison
Below is a patient-focused overview of the main prescription weight-loss injections available in the UK.
Semaglutide (Wegovy)
This is the same active ingredient as Ozempic, which is only licensed for diabetes.
Best for: Patients seeking strong, clinically proven weight loss with weekly dosing.
How it works:
Semaglutide is a GLP-1 receptor agonist that reduces appetite, improves fullness, and helps regulate blood sugar.
Benefits:
- Weekly injection
- Strong clinical trial results (up to ~20%+ weight loss in studies)
- Particularly effective for those with metabolic risk factors
Consider if:
You want a once-weekly medication and have a history of plateauing or regaining weight.
Tirzepatide (Mounjaro in the UK; known as Zepbound in the USA)
Best for: Patients who may benefit from dual-hormone therapy when clinically appropriate.
How it works:
Targets both GLP-1 and GIP receptors, showing promising results in international trials.
Benefits:
- High weight-loss potential (20–25% in some cases)
- Weekly dosing
Consider if:
You want to explore options likely to become available in the UK soon and would like to be considered once eligibility expands.
Retatrutide
This drug has excellent results but it is not yet licensed in the UK. If you see it being sold, it may be counterfeit because there is no legal option outside of a formal UK-led trial.
Which Injection Is Right for You?
The answer depends on several factors:
- Your current weight and BMI
- Medical history and medications
- Previous attempts with weight-loss treatments
- Whether you have experienced regain after surgery
- Whether you prefer weekly or daily dosing
- Your goals, timeline, and lifestyle
There is no single “best” injection - only the best option for your circumstances.
At Harley Street Obesity Clinic, we take an interest in you as an individual. We consider your full medical background, help you understand every option, and design a treatment plan that supports long-term success.
Why Choose a Specialist Clinic Instead of Buying Online?
Many patients ask whether they should order weight-loss injections online or from prescription-only websites. Our approach is different:
- Full clinical assessment and safety monitoring
- Support throughout your programme
- Guidance if you plateau or regain weight
- Revision options if you have had bariatric surgery
- No hidden fees — postage included
- Transparent pricing and £20 off your first prescription
Your treatment is not just a transaction; it is a medically guided journey.
Start Your Personalised Weight-Loss Plan
If you’re unsure which weight loss injection is best for you, we can help you compare options based on your body, your history, and your goals.
Harley Street Obesity Clinic
Expert-led, patient-focused, with a proven track record in safe and sustainable weight management.